hyze-labs-2 Electric Boogaloo

Registered Phenomena Code: XXX

Object Class:

Hazard Types: Biohazard.

orthohepadnavirus.png

RPC-XXX visualized through tunneled electron microscope.

Containment Protocols: Samples of RPC-XXX are to be contained in a hepatic cell line, kept in an enriched viral culture medium, at a temperature between 36°C and 36.5°. The Petri dishes containing this medium are to be kept at the Virology Lab of the Research Wing of Site-008 and are to be monitored daily to replace nutrients on the medium. Testing with RPC-XXX is to be done following Level 3 Biohazard guidelines. Upon suspected exposure, subjects are to be put under quarantine and undergo the treatment detailed in Addendum 1.

Description: RPC-XXX designates a virus closely associated to the Hepadnaviridae1 family and Orthohepadnavirus2 genus, however research shows the agent belongs to a species uncatalogued as of yet. RPC-XXX displays a spherical symmetry with an icosahedral shape, enveloped by a proteic capsid containing a double chain DNA strand.

RPC-XXX is transmitted sexually via exposure to infectious bodily fluids and testing with other creatures has deemed the only known reservoir for this virus is humans. Upon entering the body through any of these means, RPC-XXX travels to the liver via blood circulation. Upon reaching it, the agent will infect the hepatocytes3. Then the virus will replicate rapidly within the infected cells. Different to the way most viruses behave though, release of virions from the host cell will not result in cell death and the cell will continue to be used by the virus.

Most notably, RPC-XXX will induce a state of heightened reproductivity of the cells it infects, creating a cellular line similar in behavior to HeLa cells4. The modified cells will then divide rapidly and arrange themselves through complex biochemical sequences to form a very differentiated, functional neoplasm identical to the liver it originated from, with the formation of new blood vessels to supply the organ through understood and non anomalous biochemical processes.

Individuals infected by RPC-XXX typically exhibit a moderate fever, associated with palpable masses located where the liver is found on their body and sometimes exhitibing mild jaundice. These individuals notably exhibit a higher tolerance to noxious effects from toxins and drugs administered to them due to heightened hepatic metabolism. Testing has shown that using highly hepatotoxic drugs or surgically removing segments of the liver accelerates the cellular proliferation induced by the virus. Radical hepatectomy of the subject has proven effective at curing the host when combined with antiviral drugs.

When infected individuals are left without treatment, the replication of hepatocytes will go on unchecked, reaching a point where it is not possible for the human body to sustain the neoplasms, besides the increase in fat and carbohydrate deposits leading to various diseases that lead to the subject's death. Upon death of the subject, if left without sustenance the infected cells eventually die, however if placed in an enriched, viral culture medium the cells will remain mitotically active and eventually form liver tissue until the nutrients of the medium are used up.

Discovery: RPC-XXX was discovered by Authority personnel after reports of an atypical form of Hepatitis from various hospitals around [REDACTED] surfaced in 20/01/20██. Investigations found several patients afflicted by a previously uncatalogued form of hepatocellular cancer, succumbing to the heightened metabolism of their livers. Some patients were taken into Authority medical facilities for treatment and research, with the issuing of a cover story about an hepatitis B outbreak afflicting the most populated areas of [REDACTED].

A few of the patients taken in for medical care in Authority facilities were found to have serial numbers tattooed on the skin on the back of their right shoulder, below which "Lakebed Laboratory Research" could be read. Investigations as to an underwater facility located in any Canadian lake are undergoing.

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